The article deals with entrepreneurship in local development. It maintain the utility of focused analysis of specific situations and suggest that the individualistic paradigm of analysis allows combined interpretations of different social sciences perspectives. The middle-range theory of social capital seems an useful instrument for the particular perspective of sociology in this interdisciplinary game. The social capital is intended as a localized resource for entrepreneurial action. In reference to that particular resource, the paper concludes that specific national policies can improve the mobilization and formation of appropriated social capital for entrepreneurship in local economic systems, encouraging the cooperation of different local private and public actors for long-term and coordinated strategies of growth.