Susanna Bergamaschi Chiara Spironelli Lucia Cesaro Mirella Manfredi Attilio Calza Sara Mondini

Learning effects and cortical re-organization in patients with Alzheimer disease

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The aim of the study was to investigate, in patients with AD, the effects of one-month cognitive stimulation training with the repetition of a cognitive task. Reaction times on answers and cortical activity (ERP) were measured during the execution of a trained task and a control task. Pre- and post-training comparisons showed: (1) faster and more accurate responses after the training in both the trained and the control task; (2) different pattern of neural network activation during the trained task. Thus, an intense cognitive training in AD patients modulated learning behaviour as well as plastic re-organizations of cerebral networks.


  • Alzheimer's disease
  • cognitive stimulation training
  • evoked potentials
  • cortical plasticity
  • reaction times


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